Loan signing Michael Spillane is expected to be promoted from the bench in place of Rossi Jarvis while Tristan Plummer could figure in attack.
Loanee Craig Cathcart could play for Plymouth after Manchester United have given permission for him to play.
Defensive duo Gary Sawyer and David McNamee are both ruled out of the tie by hamstring injuries.
Teams tonight can name 7 subs but only three can be used.League 2 side Luton remain on -30 points after losing their opening game of the season. They have a chance of survival because of 17 point deductions for Bournemouth and Rotherham.