Patterson, fresh from his goal for Northern Ireland, came off the bench in Saturday's defeat to Brentford and will be looking for a promotion to the starting line-up.
Carl Fletcher has been absent from the Argyle side for the last seven matches after suffering a leg injury and has returned to training but Tuesday's game is likely to come too soon for the midfielder.
Goalkeeper David Button has also occupied the sidelines with a leg injury and is close to a return as is Jim Paterson who has returned to full training following a torn hamstring but is unlikely to be risked yet.
Stephane Zubar impressed on his debut at right-back and is likely to keep his place.
Source: PA
Source: PA