The big striker has been sidelined since early January with a ruptured thigh, but he resumed full training earlier this month and looks set to feature at the weekend.
Rowan Vine - back in the side after a year out with a broken leg - and Heidar Helguson are likely to start in attack with Agyemang set to be named on the bench.
Rangers have no fresh injury concerns as caretaker boss Gareth Ainsworth looks to end another turbulent season on a winning note.
Skipper Martin Rowlands and fellow midfielder Akos Buzsaky are the only absentees, with both hoping to be fit for next season.
Plymouth Argyle manager Paul Sturrock is set to name an unchanged side.
Argyle still need another win to be sure of avoiding relegation after last weekend's 3-0 home defeat to Doncaster, but Sturrock is unlikely to make changes to his starting line-up.
On-loan Manchester United defender Craig Cathcart is still ruled out with a knee injury, and Sturrock fears the centre-back could also be ruled out of the final game of the season against Barnsley.
Chris Barker will continue to deputise at the heart of defence, but there could be changes on the bench for the Pilgrims, with Rudi Douala (knee) and Craig Noone both hoping for spots after scoring for the reserves in midweek.
And fellow striker Steve MacLean will also be pushing for a spot among the replacements at Loftus Road after recovering from a knee injury of his own.
Sporting Life