"If we give Reading chances like we did to Luton, I can assure you they are the type of team who will plunder you."
Argyle could include new signing Craig Noone is the starting line up and there's likely to be a Championship debut for Craig Cathcart.
Reading will be with right-back and captain Graeme Murty against as he is sidelined with a calf injury.
Midfielder Marek Matejovsky sustained an ankle injury in last weekend's goalless draw at Nottingham Forest and will be out for around three weeks.