After the 2 - 1 win at Watford last Tuesday Paul Sturrock's side beat Palace by the same scoreline.
Paul Gallagher's brace ended Crystal Palace's unbeaten home record. Paddy McCarthy's 85th minute goal for the home side proved to be just a consolation.
The two wins have seen Plymouth jump to 18th in the table with 8 points from 7 games.
Next up it's Nottingham Forest at Home Park.